abstract：:Collagenolytic activity of rat kidneys with streptozotocin diabetes was estimated by means of a biological collagenase assay and compared to healthy controls. Collagenolytic activity was found significantly decreased in rat kidneys with diabetes correlating with blood glucose levels (r = -0.82, p less than 0.001). Ele...

journal_title：Nephron

authors： Lubec G,Leban J,Peyroux J,Sternberg M,Pollak A,Latzka U,Coradello H

更新日期：1982-01-01 00:00:00

abstract：:The daily urinary excretion of oxalate has been found to be lower than normal in patients with renal failure and the decrease to be directly proportional to the impairment of renal function. It has also been found that the gut flora from uremic patients destroys oxalate 'in vitro' more efficiently than the gut flora f...

journal_title：Nephron

authors： Camici M,Balestri PL,Lupetti S,Colizzi V,Falcone G

更新日期：1982-01-01 00:00:00

abstract：:Nephrotic range proteinuria occurred in a 60-year-old woman with renal artery stenosis and marked hyperreninemia. Treatment by nephrectomy produced resolution of both proteinuria and hypertension. The gradual resolution of the proteinuria postoperatively suggested the proteinuria, at least in part, came from the contr...

journal_title：Nephron

authors： Eiser AR,Katz SM,Swartz C

更新日期：1982-01-01 00:00:00

abstract：:4 patients on regular dialysis were studied by the echocardiographic method during ultrafiltration and dialysis performed sequentially according to two different protocols. Blood pressure, heart rate, cardiac output, stroke volume, systolic and diastolic dimension of the left ventricle, systolic and diastolic volumes ...

journal_title：Nephron

authors： Cini G,Camici M,Pentimone F,Palla R

更新日期：1982-01-01 00:00:00

abstract：:The physiologic action of prazosin in man was studied in 23 patients including 10 treated with prazosin plus polythiazide. Responders to prazosin alone (blood pressure fell greater than 10 mm Hg) had a decrease in peripheral resistance (p less than 0.02) and no significant change in plasma volume, while nonresponders'...

journal_title：Nephron

authors： Blaufox MD,Ross L,Koshy K,Lee HB

更新日期：1981-01-01 00:00:00

abstract：:It has been generally accepted that acidosis results in hyperkalemia because of shifts of potassium from the intracellular to the extracellular compartment. There is ample clinical and experimental evidence, however, to support the conclusion that uncomplicated organic acidemias do not produce hyperkalemia. In acidosi...

journal_title：Nephron

authors： Perez GO,Oster JR,Vaamonde CA

更新日期：1981-01-01 00:00:00

abstract：:Urate deposits within microtophi were found in 8% of unselected autopsies in Brisbane, Australia. Significant association were demonstrated with (a) a history of gouty arthritis and (b) the existence of nitrogen retention and renal disease of apparently primary, but not gouty, origin. However, in 26% of the patients, ...

journal_title：Nephron

authors： Linnane JW,Burry AF,Emmerson BT

更新日期：1981-01-01 00:00:00

abstract：:The decreases in serum osmolality as well as the rate of ultrafiltration during hemodialysis and the influence of each upon the side effects of this treatment were studied in 13 chronic stable dialysis patients. Mannitol (9 mosm/kg water) was infused in two out of four dialyses, in a double blind fashion. A solution o...

journal_title：Nephron

authors： Rosa AA,Shideman J,McHugh R,Duncan D,Kjellstrand CM

更新日期：1981-01-01 00:00:00

abstract：:Serum prolactin levels were elevated in male Sprague-Dawley rats with acute renal failure induced by glycerol administration. Specific prolactin binding to kidney membrane preparations was reduced in glycerol and antirat glomerular basement membrane serum-treated rats, after morphological and biochemical acute renal f...

journal_title：Nephron

authors： Dobbie JW,Mountjoy K,Cowden EA,Allison ME,Ratcliffe JG

更新日期：1981-01-01 00:00:00

abstract：:351 sera from 27 human recipients of renal allografts and 21 healthy blood donors were assayed for circulating immune complexes by the Clq solid-phase radioimmune assay. Increased Clq-binding activity (Clq-BA) was detected in pretransplant sera from 5 patients with chronic pyelonephritis (PN) and 3 patients with chron...

journal_title：Nephron

authors： Kaden J,Falck P,Groth J,Mebel M

更新日期：1981-01-01 00:00:00

abstract：:Nephrotoxic agents such as puromycin aminonucleoside (PAN) and sodium maleate (MAL) have been used to induce experimental glomerular proteinuria and tubular disease, respectively. Current studies show that PAN caused a massive loss of albumin in the urine while not affecting the excretion of the smaller, sex-dependent...

journal_title：Nephron

authors： Neuhaus OW,Flory W,Biswas N,Hollerman CE

更新日期：1981-01-01 00:00:00

abstract：:Creatinine clearance has been repeatedly measured in three groups of chronic uremics. In the first control group (31 cases), following a conventional low-protein diet, creatinine clearance declined linearly with time. In the second group (12 cases), following very low nitrogen diet supplemented with essential amino ac...

journal_title：Nephron

authors： Barsotti G,Guiducci A,Ciardella F,Giovannetti S

更新日期：1981-01-01 00:00:00

abstract：:Acute interstitial nephritis (AIN) has been reported in association with therapy with a number of drugs. We report a patient who developed drug-related AIN while receiving intravenous amoxicillin therapy. The patient developed rash, secondary temperature elevation, and eosinophilia in association with nonoliguric rena...

journal_title：Nephron

authors： Appel GB,Garvey G,Silva F,Francke E,Neu HC,Weissman J

更新日期：1981-01-01 00:00:00

abstract：:The high blood flow rate/gram of kidney tissue supplies mainly the renal cortex. The net effect of the interaction of the renin-angiotensin system, the kallikrein-kinin system and prostaglandins is to autoregulate renal blood flow within a narrow range. Drugs and neurogenic factors also influence renal hemodynamics. T...

journal_title：Nephron

authors： Maher JF

更新日期：1981-01-01 00:00:00

abstract：:Results from many laboratories, including our own, support the following view of the status of renal blood flow (RBF) in acute renal failure (ARF). During the initiation phase of virtually all forms of experimental ARF, RBF appears to be substantially decreased. The mechanisms for the decrease in RBF vary depending on...

journal_title：Nephron

authors： Hsu CH,Kurtz TW

更新日期：1981-01-01 00:00:00

abstract：:8 patients who developed proteinuria whilst receiving penicillamine for rheumatoid arthritis have been studied. Light microscopy of renal biopsy specimens showed evidence of an extramembranous nephropathy in 6 cases, with epimembranous spikes infrequently described previously in association with penicillamine. ...

journal_title：Nephron

authors： Ross JH,McGinty F,Brewer DG

更新日期：1980-01-01 00:00:00

abstract：:5 patients, including 4 with partial lipodystrophy and 1 with dense deposit disease (type II mesangiocapillary glomerulonephritis; MCGN), had positive C3 nephritic factor assays by both a crossed-gel immunoelectrophoretic and a magnesium-dependent hemolytic assay. One or more early classic complement component was sig...

journal_title：Nephron

authors： McLean RH,Siegel NJ,Kashgarian M

更新日期：1980-01-01 00:00:00

abstract：:Rat sera, 10-30 h after unilateral nephrectomy (UNI), enhance 3H-thymidine ("3H-Tdr) incorporation into DNA of incubating renal tissue from control rats. Stimulation is even greater when extracts from remaining growing kidneys 20 h after UNI are combined with sera from rats after UNI. UNI extracts, i.e., extracts from...

journal_title：Nephron

authors： Castillo O,Robertson D,Goldin H,Preuss HG

更新日期：1980-01-01 00:00:00

abstract：:The Spanish brush goat (Capra hiricus) was studied as an animal model for the anephric state. This rugged animal has a hardy appetite and offers ready blood access for dialysis and sampling. BUN, plasma creatinine and potassium could be brought to normal values by daily hemodialysis. Continual weight loss, severe anem...

journal_title：Nephron

authors： Bower JD,Holbert RD,Pearson JE,Jones Q,Bengis R,Berndt WO

更新日期：1980-01-01 00:00:00

abstract：:Dialysate effluent protein content was measured in 22 patients undergoing continuous ambulatory peritoneal dialysis (9 with and 13 without previous peritonitis). The average amount of protein in those patients without peritonitis was 1.3 g/2 liters exchanged over a 6-hour period, while that of patients with previous p...

journal_title：Nephron

authors： Katirtzoglou A,Oreopoulos DG,Husdan H,Leung M,Ogilvie R,Dombros N

更新日期：1980-01-01 00:00:00

abstract：:A previously described method for recovering a proximal renal tubular epitheal antigen (HRTE-1) from normal human kidney was modified by using ion-exchange and immunoaffinity chromatography in order to create easily reproducible conditions for antigen isolation. Radioiodinated HRTE-1 was then used to establish a 3-hou...

journal_title：Nephron

authors： Zager RA,Rubin NT,Ebert T,Maslov N

更新日期：1980-01-01 00:00:00

abstract：:The local cutaneous inflammatory response to DMCB sensitization was positive in only 35% of 20 uremic patients, and the delayed skin reaction was positive in only 15%. The reaction to DMCB challenge was markedly delayed in some patients. Improved response to DNCB re-challenge followed levamisole administration in only...

journal_title：Nephron

authors： Modai D,Sagi DB,Maor J

更新日期：1980-01-01 00:00:00

abstract：:After successful renal transplantation there is continuing malabsorption of calcium and phosphorus. This is due in part to impaired glomerular filtration rate, and in part to the action of steroid on calcium and phosphorus absorption. The effect of steroids is most marked over the first 18 months after transplantation...

journal_title：Nephron

authors： Walker GS,Peacock M,Marshall DH,Giles GR,Davison AM

更新日期：1980-01-01 00:00:00

abstract：:The physicians in charge of 15 German hemodialysis units furnished data on 713 dialysis patients. Data relating to the vocational status were examined for 612 patients aged 60 years or below. It was found that the current working status varies with psychological and social factors. The data show that the vocational st...

journal_title：Nephron

authors： Tews HP,Schreiber WK,Huber W,Zelt J,Ritz E

更新日期：1980-01-01 00:00:00

abstract：:Serum specimens from 99 selected renal patients were examined over a 3-year period by both a hemagglutination technique (HA) and an indirect immunofluorescent (IIF) method for the presence of circulating antibody against tubular basement membrane (TBM). 11 patients were found with anti-TBM antibodies. 6 of them also h...

journal_title：Nephron

authors： Cattran DC

更新日期：1980-01-01 00:00:00

abstract：:The role of renal hemodynamic alterations in the curtailment of renal functions was studied in uranyl acetate-induced oliguric (ORF) and nonoliguric (NORF) renal failures of rabbits. 5 days after drug injection, renal functional and morphological changes were most remarkable. A depression of Cin and elevation of serum...

journal_title：Nephron

authors： Sudo M,Honda N,Hishida A,Nagase M

更新日期：1980-01-01 00:00:00

abstract：:Classic renal tubular acidosis is characterized by a primary defect in establishment of a large hydrogen ion gradient across the distal renal tubule. Thus the development of hyperchlorenic metabolic acidosis follows. In addition, hypokalemia results from renal potassium wasting secondary hyperaldosteronism from sodium...

journal_title：Nephron

authors： Chan JC

更新日期：1979-01-01 00:00:00

abstract：:In an effort to elucidate immunopathogenic of membranous nephropathy (MN), freshly collected sera from patients with biopsy proven MN were assayed of circulating immune complexes (ICs) by the Raji cell method and for anti-renal tubular epithelial (RTE) antibodies by a newly established radioimmunoassay (RIA) and by in...

journal_title：Nephron

authors： Zager RA,Couser WG,Andrews BS,Bolton WK,Pohl MA

更新日期：1979-01-01 00:00:00

abstract：:This paper reviews the control of aldosterone secretion, including the role played by hepatic metabolic clearance, ACTH, and the renin-angiotensin system, and the interrelationships of aldosterone secretion with sodium and potassium metabolism. The physiological modulations of aldosterone secretion by the upright post...

journal_title：Nephron

authors： Chan JC

更新日期：1979-01-01 00:00:00

abstract：:An 'epidemic' of aseptic peritonitis occurred in our peritoneal dialysis unit, affecting 5 of 20 patients. Acute and convalescent viral titers were normal in all 5. The peritoneal fluid of the affected patients was not tested for endotoxin, but endotoxin was found in subsequent dialysis fluids from two machines in the...

journal_title：Nephron

authors： Gandhi VC,Kamadana MR,Ing TS,Daugirdas JT,Viol GW,Robinson JA,Geis WP,Hano JE

更新日期：1979-01-01 00:00:00

abstract：:Renal biopsy specimens obtained from patients with various chronic nephropathies were studied by immunofluorescence (IF), electron and light microscopy. Of 49 biopsies studied by IF, 22 had granular deposits of IgG and/or C3 along the basement membranes of proximal tubules while 14 had linear and 13 both linear and gr...

journal_title：Nephron

authors： Orfila C,Rakotoarivony J,Durand D,Suc JM

更新日期：1979-01-01 00:00:00

abstract：:A critical survey of the literature suggests that elevated serum uric acid is definitely associated with hypertension and may function as an independent risk factor in the development of this disease. The possible role of an elevated serum uric acid as an independent risk factor for the development of ischemic heart d...

journal_title：Nephron

authors： Tweeddale MG,Fodor JG

更新日期：1979-01-01 00:00:00

abstract：:Plasma concentrations of norepinephrine (NE) appear to reflect sympathetic nervous system (SNS) tone. Plasma NE increases substantially when the SNS is stressed by acute postural change or physical exercise. Standing up from the recumbent position elevates NE by about 90% in healthy normotensive and hypertensive subje...

journal_title：Nephron

authors： Lake CR

更新日期：1979-01-01 00:00:00

abstract：:29 patients receiving haemodialysis treatment for chronic renal failure were divided into two groups on the basis of the presence or absence of bone disease as defined by radiology and bone alkaline phosphatase. The group of patient with bone disease showed a significantly greater increase in protein-bound calcium dur...

journal_title：Nephron

authors： Gosling P,Naik RB,Price CP,Sammons HG,Robinson BH

更新日期：1979-01-01 00:00:00

abstract：:Mitochondria contain electron-dense particles, partly composed of an amorphous form of calcium phosphate. We have used electron microscopy from percutaneous renal biopsy material to analyze mitochondrial granulation in the proximal renal tubule of nonuremic and uremic children. Based on a technique of cutting mitochon...

journal_title：Nephron

authors： Whitney JO,Goodman JR,Piel CF

更新日期：1979-01-01 00:00:00

abstract：:Renin substrate concentrations and the release of renin in response to the rapid removal of 15 ml/kg weight blood or subcutaneous administration of 500 microgram/kg body weight isoproterenol were measured in control rats and animals recovering from prior myohemoglobinuric acute renal failure (recovery rats). Blood for...

journal_title：Nephron

authors： Carvalho JS,Landwehr DM,Oken DE

更新日期：1978-01-01 00:00:00

abstract：:A retrospective study of 100 patients followed for 1-4 years after successful renal transplantation was undertaken to assess the amelioration of previously present metabolic bone disease and to determine the risk factors associated with the development of osteonecrosis. 42% of patients showed some evidence of bony abn...

journal_title：Nephron

authors： Gottlieb MN,Stephens MK,Lowrie EG,Griffiths HJ,Kenzora J,Strom TB,Lazarus JM,Tilney NL,Merrill JP

更新日期：1978-01-01 00:00:00

abstract：:Using a 2-hour 47Ca absorption test, significant depression of active calcium absorption was demonstrated in 48 vitamin D untreated haemodialysis patients. This malabsorption of calcium could be corrected by the daily oral administration of 1--2 microgram of 1alphaOHD3 and 1--1.5 microgram of 1,25(OH)2D3. 5 microgram ...

journal_title：Nephron

authors： Pierides AM,Aljama P,Kerr DN,Scott M,Norman AW

更新日期：1978-01-01 00:00:00

abstract：:A 4-year-old girl, who had been in perfect health, presented with the acute onset of renal failure and abdominal mass. Investigations revealed a solitary left kidney which on histology had the typical features of xanthogranulomatous pyelonephritis. The child had no previous history suggestive of chronic renal disease ...

journal_title：Nephron

authors： Noah M,Schoeneman MJ,Haycock G,Levitt SB,Bennett B,Greifer I

更新日期：1978-01-01 00:00:00

abstract：:The effect of ischemia on renal blood flow (RBF) in the rat has been an unsettled question. This study used a totally extractable indicator, radioactive microspheres, with a reference arterial sample, to study RBF quantitatively 10 and 60 min after 1 h of unilateral renal artery clamping in anesthetized, heparinized r...

journal_title：Nephron

authors： Riley AL

更新日期：1978-01-01 00:00:00